# name
C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.

# metadata.dc.description.abstract[].value
The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation of c-Myc in liver causes disorganized organ architecture, decreased hepatocyte size, and cell ploidy. Furthermore, c-Myc appears to have distinct roles in proliferation in liver. Thus, postnatal hepatocyte proliferation does not require c-Myc, whereas it is necessary for liver regeneration in adult mice. These results show novel physiological functions of c-myc in liver development and hepatocyte proliferation and growth.

# metadata.dc.relation.ispartof[].value
Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2005, vol. 102, num. 20, p. 7286-7291

# metadata.dc.rights[].value
cc-by-nc-nd (c) Baena, Esther et al., 2005

# metadata.dc.source[].value
Articles publicats en revistes (Biomedicina)

# metadata.dc.title[].value
C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.