# name
Fracture risk after deprescription of bisphosphonates: Application of real-world data in primary care

# metadata.dc.description.abstract[].value
Purpose: To compare the effect of discontinuing bisphosphonate treatment on fracture risk in postmenopausal women at high versus low risk of fracture.Design: Retrospective, longitudinal and population-based cohort study.Setting: Barcelona City Primary Care. Catalan Health Institute. Participants: All women attended by primary care teams who in January 2014 had received bisphosphonate treatment for at least five years were included and followed for another five years.Intervention: Patients were classified according to their risk of new fractures, defined as those who had a history of osteoporotic fracture and/or who received treatment with an aromatase inhibitor, and the continuity or deprescription of the bisphosphonate treatment was analyzed over fiver year follow-up.Main measurements: The cumulative incidence of fractures and the incidence density were calculated and analyzed using logistic regression and Cox models.Results: We included 3680 women. There were no significant differences in fracture risk in high-risk women who discontinued versus continued bisphosphonate treatment (hazard ratio [HR] 1.17, 95% confidence interval [CI] 0.87--1.58 for total osteoporotic fractures). However, discontinuers at low risk had a lower incidence of fracture than continuers. This difference was significant for vertebral fractures (HR 0.64, 95% CI 0.47-0.88) and total fractures (HR 0.77, 95% CI 0.64-0.92).

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Atención Primaria, 2023, vol. 55, num. 7

# metadata.dc.rights[].value
cc by-nc-nd (c) Troncoso Mariño, Amelia et al, 2023

# metadata.dc.source[].value
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

# metadata.dc.title[].value
Fracture risk after deprescription of bisphosphonates: Application of real-world data in primary care