# name
Marine organism sulfated polysaccharides exhibiting significant
                antimalarial activity and inhibition of red blood cell invasion
                by Plasmodium

# metadata.dc.description.abstract[].value
The antimalarial activity of heparin, against which there are no
                resistances known, has not been therapeutically exploited due to
                its potent anticoagulating activity. Here, we have explored the
                antiplasmodial capacity of heparin-like sulfated polysaccharides
                from the sea cucumbers Ludwigothurea grisea and Isostichopus
                badionotus, from the red alga Botryocladia occidentalis, and
                from the marine sponge Desmapsamma anchorata. In vitro
                experiments demonstrated for most compounds significant
                inhibition of Plasmodium falciparum growth at low-anticoagulant
                concentrations. This activity was found to operate through
                inhibition of erythrocyte invasion by Plasmodium, likely
                mediated by a coating of the parasite similar to that observed
                for heparin. In vivo four-day suppressive tests showed that
                several of the sulfated polysaccharides improved the survival of
                Plasmodium yoelii-infected mice. In one animal treated with I.
                badionotus fucan parasitemia was reduced from 10.4% to
                undetectable levels, and Western blot analysis revealed the
                presence of antibodies against P. yoelii antigens in its plasma.
                The retarded invasion mediated by sulfated polysaccharides, and
                the ensuing prolonged exposure of Plasmodium to the immune
                system, can be explored for the design of new therapeutic
                approaches against malaria where heparin-related polysaccharides
                of low anticoagulating activity could play a dual role as drugs
                and as potentiators of immune responses.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1038/srep24368

# metadata.dc.relation.ispartof[].value
Scientific Reports, 2016, num. 6 , p. 1-14

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Marine organism sulfated polysaccharides exhibiting significant
                antimalarial activity and inhibition of red blood cell invasion
                by Plasmodium