# name
Maternal Smoking during Pregnancy and Early Childhood and
                Development of Asthma and Rhinoconjunctivitis - a MeDALL Project

# metadata.dc.description.abstract[].value
BACKGROUND: The role of tobacco smoke exposure in the
                development and persistence of asthma and rhinoconjunctivitis
                through childhood into adolescence is unclear. OBJECTIVES: We
                assessed the associations of parental smoking from fetal life
                through adolescence with asthma and rhinoconjunctivitis during
                childhood and adolescence. METHODS: We analyzed data for 10,860
                participants of five European birth cohort studies from the
                Mechanisms of the Development of Allergy (MeDALL) consortium.
                Parental smoking habits and health outcomes (early transient,
                persistent, and adolescent-onset asthma and rhinoconjunctivitis)
                were based on questionnaires covering the period from pregnancy
                to 14-16 y of age. Data were combined and analyzed using a
                one-stage and two-stage individual participant data
                meta-analysis. RESULTS: Overall, any maternal smoking during
                pregnancy tended to be associated with an increased odds of
                prevalent asthma [adjusted odds ratio (aOR)=1.19 (95% CI: 0.98,
                1.43)], but not prevalent rhinoconjunctivitis [aOR=1.05 (95% CI:
                0.90, 1.22)], during childhood and adolescence. In analyses with
                phenotypes related to age of onset and persistence of disease,
                any maternal smoking during pregnancy was associated with early
                transient asthma [aOR=1.79 (95% CI: 1.14, 2.83)]. Maternal
                smoking of >/=10 cigarettes/day during pregnancy was
                associated with persistent asthma [aOR=1.66 (95% CI: 1.29,
                2.15)] and persistent rhinoconjunctivitis [aOR=1.55 (95% CI,
                1.09, 2.20)]. Tobacco smoke exposure during fetal life, infancy,
                childhood, and adolescence was not associated with
                adolescent-onset asthma or rhinoconjunctivitis. CONCLUSIONS:
                Findings from this combined analysis of five European birth
                cohorts strengthen evidence linking early exposure to tobacco
                smoke with asthma during childhood and adolescence. Children
                with high early-life exposure were more likely than unexposed
                children to have early transient and persistent asthma and
                persistent rhinoconjunctivitis. https://doi.org/10.1289/EHP2738.

# metadata.dc.publisher[].value
National Institute of Environmental Health Sciences

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1289/EHP2738

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Maternal Smoking during Pregnancy and Early Childhood and
                Development of Asthma and Rhinoconjunctivitis - a MeDALL Project