# name
High prevalence of Pneumocystis jirovecii pneumonia among
                Mozambican children < 5 years of age admitted to hospital
                with clinical severe pneumonia

# metadata.dc.description.abstract[].value
We aimed to describe Pneumocystis jirovecii pneumonia (PCP)               prevalence and features in children from sub-Saharan Africa, and
                to investigate PCP-associated risk factors. During 2006-2007 we
                used molecular methods to test children younger than 5 years old
                admitted with severe pneumonia to a hospital in Southern
                Mozambique for Pneumocystis infection. We recruited 834
                children. PCP prevalence was 6.8% and HIV prevalence was 25.7%.
                The in-hospital and delayed mortality were significantly higher
                among children with PCP (20.8% vs. 10.2 %, p=0.021, and 11.5%
                vs. 3.6%, p=0.044, respectively). Clinical features were mostly
                overlapping between the two groups. Independent risk factors for
                PCP were age less than a year (OR 6.34, 95%CI 1.86-21.65), HIV
                infection (OR 2.99, 95%CI 1.16-7.70), grunting (OR 2.64, 95%CI
                1.04-6.73), and digital clubbing (OR 10.75, 95%CI 1.21-95.56).
                PCP is a common and life-threatening cause of severe pneumonia
                in Mozambican children. Mother-to-child HIV transmission
                prevention should be strengthened. Better diagnostic tools are
                needed.

# metadata.dc.relation.isformatof[].value
Versió postprint del document publicat a:
                http://dx.doi.org/10.1016/j.cmi.2015.07.011

# metadata.dc.rights[].value
cc by-nc-nd (c) European Society of Clinical Microbiology and Infectious Diseases, 2015

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
High prevalence of Pneumocystis jirovecii pneumonia among
                Mozambican children < 5 years of age admitted to hospital
                with clinical severe pneumonia