# name
A role for caspase-8 and TRAIL-R2/DR5 in ER-stress induced apoptosis

# metadata.dc.description.abstract[].value
Glab and colleagues examine in a recent paper apoptosis induced by some driverss of
endoplasmic reticulum (ER) stress. They conclude that in contrast to a previously published
report2
, DR5/TRAIL-R2 and caspase-8 are universally dispensable in ER stress-induced
apoptosis. We argue here that their own data and other published reports indicate that in
many models, DR5 and/or caspase-8 are essential players in apoptosis mediated by the
unfolded protein response (UPR), upon chronic ER stress.

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Cell Death & Differentiation, 2017, num. 1 October

# metadata.dc.source[].value
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

# metadata.dc.title[].value
A role for caspase-8 and TRAIL-R2/DR5 in ER-stress induced apoptosis