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A synthetic approach to ervatamine-silicine alkaloids. Enantioselective total synthesis of (-)-episilicine

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Starting from an appropriate unsaturated phenylglycinol-derived oxazolopiperidone lactam, the synthesis of (-)-16-episilicine is reported, the key steps being a stereoselective conjugate addition, a stereoselective alkylation, and a ring-closing metathesis reaction. This represents the first enantioselective total synthesis of an alkaloid of the silicine group.

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Journal of Organic Chemistry, 2010, vol. 75, num. 1, p. 178-189

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

# metadata.dc.title[].value
A synthetic approach to ervatamine-silicine alkaloids. Enantioselective total synthesis of (-)-episilicine