Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.

Sancho Balsells, AnnaBorràs Pernas, SaraBrito, VerónicaAlberch i Vié, Jordi, 1959-Girault, Jean-AntoineGiralt Torroella, Albert2024-02-152024-02-152023-02-141661-6596https://hdl.handle.net/2445/207574We found that specific manipulation of superficial but not deep pyramidal neurons of the CA1 resulted in the amelioration of depressive-like behaviors and the restoration of cognitive impairments induced by chronic stress. In summary, Egr1 might be a core molecule driving the activation/deactivation of hippocampal neuronal subpopulations underlying stress-induced alterations involving emotional and cognitive sequels.21 p.application/pdfengcc-by (c) Sancho-Balsells A. et al., 2023http://creativecommons.org/licenses/by/4.0/Hipocamp (Cervell)NeuronesMemòriaEsquizofrèniaDepressió psíquicaEstrès (Psicologia)Hippocampus (Brain)NeuronsMemorySchizophreniaMental depressionStress (Psychology)Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.info:eu-repo/semantics/article10.3390/ijms240438337421812024-02-15info:eu-repo/semantics/openAccess36835243