Soria Utrilla, VirginiaSasso, Corina VerónicaRomero Zerbo, Silvana YaninaAdarve Castro, AntonioLópez Urdiales, RafaelHerranz Antolín, SandraGarcía Almeida, José ManuelGarcía Malpartida, KatherineFerrer Gómez, MercedesMoreno Borreguero, AliciaLuengo Pérez, Luis MiguelÁlvarez Hernández, JuliaAragón Valera, CarmenOcón Bretón, María JuliaGarcía Manzanares, ÁlvaroBretón Lesmes, IreneSerrano Aguayo, PilarPérez Ferre, NataliaLópez Gómez, Juan JoséOlivares Alcolea, JosefinaMoreno Martínez, MacarenaTejera Pérez, CristinaGarcía Arias, SaraAbad González, Ángel LuisAlhambra Expósito, María RosaZugasti Murillo, AnaParra Barona, JuanTorrejón Jaramillo, SaraAbuin, JoséFernández García, José CarlosOlveira, Gabrielthe Nutrition Area of the Spanish Society of Endocrinology and Nutrition (SEEN)2025-04-162025-04-162025-01-010261-5614https://hdl.handle.net/2445/220497Background and aims: Parenteral nutrition (PN) composition could play a role in the management of systemic inflammatory response and intestinal barrier disruption. We aimed to evaluate changes in biomarkers of inflammation, oxidative status and intestinal permeability in patients with type 2 diabetes mellitus (T2DM) who received different PN lipid formulas. Methods: This was a prospective study, including 94 patients with T2DM who received omega (n)-3 polyunsaturated fatty acids (PUFA)-enriched PN, a mixture of medium and long chain triglycerides (MCT/ LCT) PN, or an olive oil-based PN. Serum levels of biomarkers of oxidative status, intestinal permeability and inflammation biomarkers were determined at day 1 and day 5 after PN initiation. Registered under ClinicalTrials.gov Identifier no. NCT02706119. Results: At day 5 after the onset of PN, the MCT/LCT group had a significant reduction of 2 proinflammatory cytokines [interleukin (IL)-15, IL-17A], elevation of the anti-inflammatory cytokine IL-13 and increase of zonulin and indoxylsulfate. The olive oil group showed a statistically significant reduction of 5 proinflammatory cytokines [IL-1D, IL-17A, IL-6, cytokine-leukemia inhibitory factor (LIF) and tumor necrosis factor alpha (TNF-a)] and reduced concentrations of the anti-inflammatory cytokine IL-1RA, while the n-3 PUFA-enriched group presented a statistically significant reduction of 8 proinflammatory cytokines (interferon-gamma, IL-1D, IL-15, IL-17A, IL-6, LIF, monocyte chemoattractant protein 1, and TNF-a). In the between-group comparisons, indoxylsulfate significantly increased in the MCT/LCT group compared to the n-3 PUFA-enriched group, while 8-isoprostane and indoxylsulfate significantly increased in the MCT/LCT group compared to the other groups and superoxide dismutase significantly decreased in the MCT/LCT group compared to the other groups. Conclusion: In patients with T2DM, PN lipid composition exerts a profound impact on proinflammatory, prooxidative and intestinal permeability biomarkers.10 p.application/pdfengcc-by-nc-nd (c) Soria Utrilla, Virginia et al., 2024http://creativecommons.org/licenses/by-nc-nd/3.0/es/PermeabilitatIntestinsDiabetis no-insulinodependentMarcadors bioquímicsPermeabilityIntestinesNon-insulin-dependent diabetesBiochemical markersinfo:eu-repo/semantics/article2025-04-03info:eu-repo/semantics/openAccess39672082