Amat Tusón, MercedesSubrizi, FabianaElias, VivianeLlor Brunés, NúriaMolins, EliesBosch Cartes, Joan2020-06-042020-06-042012-101434-193Xhttps://hdl.handle.net/2445/164259Starting from tricyclic lactam 2, which is easily accessible by cyclocondensation of -oxoester 1 with (R)-phenylglycinol, a three-step synthetic route to enantiopure 1-substituted tetrahydroisoquinolines, including 1-alkyl-, 1-aryl-, and 1-benzyl- tetrahydroisoquinoline alkaloids as well as the tricyclic alkaloid (-)-crispine A, has been developed. The key step is a stereoselective -amidoalkylation reaction using the appropriate Grignard reagent.7 p.application/pdfeng(c) Wiley-VCH, 2012Síntesi asimètricaAlcaloidesLactamesAsymmetric synthesisAlkaloidsLactamsinfo:eu-repo/semantics/article6158882020-06-04info:eu-repo/semantics/openAccess