Heyn, Holger2018-12-112018-12-112016-03-03https://hdl.handle.net/2445/126874The interpretation of noncoding alterations in cancer genomes presents an unresolved problem in cancer studies. While the impact of somatic variations in protein-coding regions is widely accepted, noncoding aberrations are mostly considered as passenger events. However, with the advance of genome-wide profiling strategies, alterations outside the coding context entered the focus, and multiple examples highlight the role of gene deregulation as cancer-driving events. This review describes the implication of noncoding alterations in oncogenesis and provides a theoretical framework for the identification of causal somatic variants using quantitative trait loci (QTL) analysis. Assuming that functional noncoding alterations affect quantifiable regulatory processes, somatic QTL studies constitute a valuable strategy to pinpoint cancer gene deregulation. Eventually, the comprehensive identification and interpretation of coding and noncoding alterations will guide our future understanding of cancer biology.9 p.application/pdfengcc by (c) Heyn, Holger, 2016http://creativecommons.org/licenses/by/3.0/es/CàncerExpressió gènicaCancerGene expressioninfo:eu-repo/semantics/article2018-07-25info:eu-repo/semantics/openAccess26938653