Picó Pérez, MariaFullana Rivas, Miguel ÀngelAlbajes Eizagirre, AntonVega, DanielMarco Pallarés, JosepVilar, AnaChamorro, JacoboFelmingham, Kim L.Harrison, Ben J.Radua, JoaquimSoriano Mas, Carles2024-06-072024-06-072022-01-110033-2917https://hdl.handle.net/2445/212660Background: Cognitive-behavior therapy (CBT) is a well-established first-line intervention for anxiety-related disorders, including specific phobia, social anxiety disorder, panic disorder/agoraphobia, generalized anxiety disorder, obsessive-compulsive disorder, and posttraumatic stress disorder. Several neural predictors of CBT outcome for anxiety-related disorders have been proposed, but previous results are inconsistent. Methods: We conducted a systematic review and meta-analysis of task-based functional magnetic resonance imaging (fMRI) studies investigating whole-brain predictors of CBT outcome in anxiety-related disorders (17 studies, n=442). Results: Across different tasks, we observed that brain response in a network of regions involved in salience and interoception processing, encompassing frontoinsular (the right inferior frontal gyrus-anterior insular cortex) and fronto-limbic (the dorsomedial prefrontal cortex-dorsal anterior cingulate cortex) cortices was strongly associated with a positive CBT outcome. Conclusions: Our results suggest that there are robust neural predictors of CBT outcome in anxiety-related disorders that may eventually lead (probably in combination with other data) to develop personalized approaches for the treatment of these mental disorders.9 p.application/pdfeng(c) Cambridge University Press (CUP), 2023AnsietatEscorça cerebralTrastorns de la cognicióImatges per ressonància magnèticaAnxietyCerebral cortexCognition disordersMagnetic resonance imaginginfo:eu-repo/semantics/article7185862024-06-07info:eu-repo/semantics/openAccess930460935916600