Orthogonal protecting groups in the synthesis of tryptophanyl-hexahydropyrroloindoles

Ruiz Sanchis, PauSavina, Svetlana A.Acosta, Gerardo A.Albericio Palomera, FernandoÁlvarez Domingo, Mercedes2014-06-022021-11-012011-11-221434-193Xhttps://hdl.handle.net/2445/54707The synthesis of various polycyclic systems containing a C3a-Ni bond between a hexahydropyrrolo[2,3-b]indole and an indole tryptophan is described here. A series of experiments were performed to determine the best combination of five orthogonal protecting groups and the best reaction conditions for formation of said bond, which is a common feature among many recently discovered marine natural products.7 p.application/pdfeng(c) Wiley-VCH Verlag GmbH & Co. KGaA, 2012Productes naturals marinsQuímica heterocíclicaAminoàcidsSíntesi de pèptidsMarine natural productsHeterocyclic chemistryAmino acidsPeptide synthesisOrthogonal protecting groups in the synthesis of tryptophanyl-hexahydropyrroloindolesinfo:eu-repo/semantics/article5985152014-05-30info:eu-repo/semantics/openAccess