Bosch Cartes, JoanBachs, JordiGómez, Antonia M.Griera Farres, RosaÉcija, MartaAmat Tusón, Mercedes2017-03-032017-03-032012-07-200022-3263https://hdl.handle.net/2445/107829Practical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide.5 p.application/pdfeng(c) American Chemical Society , 2012AntihistamínicsEstructura molecularSíntesi orgànicaAntihistaminesMolecular structureOrganic synthesisinfo:eu-repo/semantics/article6158862017-03-03info:eu-repo/semantics/openAccess