Fernández-Vega, IvánDiaz-Lucena, DanielaAzkune Calle, ItxasoGeijo, MariaJuste, Ramón A.Llorens Torres, FrancVicente Etxenausia, IkerneSantos-Juanes, JorgeZarranz, Juan J.Ferrer, Isidro (Ferrer Abizanda)2020-04-162020-04-162018-10-010919-6544https://hdl.handle.net/2445/155518Proteinase K-resistant prion protein (PrPRes ) nuclear and perinuclear immunoreactivity in oligodendrocytes of the frontal cortex is found in one case of otherwise typical sporadic Creutzfeldt-Jakob disease (sCJD) type VV2a. The PrP nature of the inclusions is validated with several anti-PrP antibodies directed to amino acids 130-160 (12F10), 109-112 (3F4), 97-102 (8G8) and the octarepeat region (amino acids 59-89: SAF32). Cellular identification and subcellular localization were evaluated with double- and triple-labeling immunofluorescence and confocal microscopy using antibodies against PrP, glial markers, and histone H3. Based on review of the literature and our own experience, this is a very odd situation that deserves further validation in other cases. Keywords: Creutzfeldt-Jakob disease; astrocytes; oligodendrocytes; prion.7 p.application/pdfeng(c) Japanese Society of Neuropathology, 2018Malaltia de Creutzfeldt-JakobNeurògliaPrionsProteïnesMetabolismePatologiaCreutzfeldt-Jakob diseaseNeurogliaPrionsProteinsMetabolismPathologyinfo:eu-repo/semantics/article6894542020-04-16info:eu-repo/semantics/openAccess30123962