Menéndez Buján, PabloSánchez Martínez, DiegoTirado Cabrera, NéstorUniversitat de Barcelona. Facultat de Medicina i Ciències de la Salut2024-12-102024-12-102024-09-20https://hdl.handle.net/2445/216990[eng] AIMS: The general aim of this doctoral thesis is to improve current CAR-T immunotherapeutic strategies in the treatment of acute leukemias. The specific aims of this doctoral thesis are: 1. To develop and characterize CD123-directed CAR-DOT cells as an allogeneic-safe, off-the-shelf therapy far the treatment of R/R AML. 2. To engineer CD1axCD3 BiTE-secreting STAb-T cells and compare their effectiveness against conventional CD1a-directed CAR-T cells against coT-ALL. 3. To generate a CCR9-directed immunotherapy far the safe treatment of R/R T-ALL. (i) To validate CCR9 as an immunotherapeutic target far T-ALL. (ii) To generate CCR9-directed CAR-T cells. (iii) To generate dual CCR9/CD1 a-directed CAR.176 p.application/pdfengcc by-nc-sa (c) Tirado Cabrera, Néstor, 2024http://creativecommons.org/licenses/by-nc-sa/3.0/es/ImmunologiaImmunoteràpiaHematologiaLeucèmia agudaImmunologyImmunotheraphyHematologyAcute leukemiainfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccesshttp://hdl.handle.net/10803/692700