Santos García, DiegoÁlvarez Sauco, MariaCalopa, MatildeCarrillo, FátimaEscamilla Sevilla, FranciscoFreire, EricGarcía Ramos, R.Kulisevsky, JaimeGómez Esteban, Juan CarlosLegarda, InésLuquín, María Rosario IsabelCastrillo, Juan Carlos MartínezMartínez Martin, PabloMartínez Torres, IreneMir, PabloIgnacio, Ángel Sesar2022-02-112022-02-112021-12-282075-4418https://hdl.handle.net/2445/183062Background and objective: Parkinson's disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients and Methods: Sixteen movement disorders specialists from Spain participated in this project. The classification was consensually approved after a discussion and review process from June to October 2021. The TNM classification and the National Institutes of Health Stroke Scale (NIHSS) were considered as models in the design. Results: The classification was named MNCD and included 4 major axes: (1) motor symptoms; (2) non-motor symptoms; (3) cognition; (4) dependency for activities of daily living (ADL). Motor axis included 4 sub-axes: (1) motor fluctuations; (2) dyskinesia; (3) axial symptoms; (4) tremor. Four other sub-axes were included in the non-motor axis: (1) neuropsychiatric symptoms; (2) autonomic dysfunction; (3) sleep disturbances and fatigue; (4) pain and sensory disorders. According to the MNCD, 5 stages were considered, from stage 1 (no disabling motor or non-motor symptoms with normal cognition and independency for ADL) to 5 (dementia and dependency for basic ADL). Conclusions: A new simple classification of PD is proposed. The MNCD classification includes 4 major axes and 5 stages to identify key symptoms and monitor the evolution of the disease in patients with PD. It is necessary to apply this proof of concept in a properly designed study.14 p.application/pdfengcc by (c) Santos García, Diego et al, 2021http://creativecommons.org/licenses/by/3.0/es/Malaltia de ParkinsonManifestacions neurològiques de les malaltiesParkinson's diseaseNeurologic manifestations of general diseasesinfo:eu-repo/semantics/article2022-02-11info:eu-repo/semantics/openAccess35054222