Domínguez García, ÀngelaSoldevila, NúriaToledo Zavaleta, Diana IsabelGodoy i García, PereEspejo, ElenaFernández, M.A.Mayoral, José MaríaCastilla, JesúsEgurrola, MikelTamames, SoniaAstray, JenaroMorales Suárez-Varela, MaríaTorner Gràcia, Núria2017-10-172017-10-172017-08-241560-7917https://hdl.handle.net/2445/116702Influenza vaccination may limit the impact of influenza in the community. The aim of this study was to assess the effectiveness of influenza vaccination in preventing hospitalisation in individuals aged ≥ 65 years in Spain. A multicentre case-control study was conducted in 20 Spanish hospitals during 2013/14 and 2014/15. Patients aged ≥ 65 years who were hospitalised with laboratory-confirmed influenza were matched with controls according to sex, age and date of hospitalisation. Adjusted vaccine effectiveness (VE) was calculated by multivariate conditional logistic regression. A total of 728 cases and 1,826 matched controls were included in the study. Overall VE was 36% (95% confidence interval (CI): 22-47). VE was 51% (95% CI: 15-71) in patients without high-risk medical conditions and 30% (95% CI: 14-44) in patients with them. VE was 39% (95% CI: 20-53) in patients aged 65-79 years and 34% (95% CI: 11-51) in patients aged ≥ 80 years, and was greater against the influenza A(H1N1)pdm09 subtype than the A(H3N2) subtype. Influenza vaccination was effective in preventing hospitalisations of elderly individuals.8 p.application/pdfengcc-by (c) Domínguez García, Àngela et al., 2017http://creativecommons.org/licenses/by/3.0/esGripVacunacióPersones gransEspanyaInfluenzaVaccinationOlder peopleSpaininfo:eu-repo/semantics/article6706632017-10-17info:eu-repo/semantics/openAccess28857047