Fàbregas, MireiaGómez Palomino, AlejandroPellicena Zanón, MiquelReina, D.F.Romea, PedroUrpí Tubella, FèlixFont Bardia, Ma. Mercedes2020-07-222020-07-222014-11-251523-7060https://hdl.handle.net/2445/169228Substrate-controlled Michael additions of the titanium-(IV) enolate of lactate-derived ketone 1 to acyclic α,β-unsaturated ketones in the presence of a Lewis acid (TiCl4 or SnCl4) provide the corresponding 2,4-anti-4,5-anti dicarbonyl compounds in good yields and excellent diastereomeric ratios. Likely, the nucleophilic species involved in such additions are bimetallic enolates that may add to enones through cyclic transition states. Finally, further studies indicate that a structurally related β-benzyloxy chiral ketone can also participate in such stereocontrolled conjugate additions.17 p.application/pdfeng(c) American Chemical Society , 2014Àcids de LewisTitaniCetonesLewis acidsTitaniumKetonesinfo:eu-repo/semantics/article6466232020-07-22info:eu-repo/semantics/openAccess