Vazirani, RaviFeltes, GiselaSánchez del Hoyo, RafaelViana Llamas, María C.Raposeiras Roubín, SergioRomero, RodolfoAlfonso Rodríguez, EmilioUribarri, AitorSantoro, FrancescoBecerra Muñoz, VíctorPepe, MartinoCastro Mejía, Alex F.Signes Costa, JaimeGonzalez, AdelinaMarín, FranciscoLopez País, JavierCerrato, EnricoVázquez Cancela, OlallaEspejo Paeres, CarolinaLópez Masjuan, ÁlvaroVelicki, LazarEl-Battrawy, IbrahimRamakrishna, HarishFernandez Ortiz, AntonioNuñez Gil, Ivan J.2024-07-152024-07-152024-04-282077-0383https://hdl.handle.net/2445/214568Background: Acute cardiac injury (ACI) after COVID-19 has been linked with unfavorable clinical outcomes, but data on the clinical impact of elevated cardiac troponin on discharge during follow-up are scarce. Our objective is to elucidate the clinical outcome of patients with elevated troponin on discharge after surviving a COVID-19 hospitalization. Methods: We conducted an analysis in the prospective registry HOPE-2 (NCT04778020). Only patients discharged alive were selected for analysis, and all-cause death on follow-up was considered as the primary endpoint. As a secondary endpoint, we established any long-term COVID-19 symptoms. HOPE-2 stopped enrolling patients on 31 December 2021, with 9299 patients hospitalized with COVID-19, of which 1805 were deceased during the acute phase. Finally, 2382 patients alive on discharge underwent propensity score matching by relevant baseline variables in a 1:3 fashion, from 56 centers in 8 countries. Results: Patients with elevated troponin experienced significantly higher all-cause death during follow-up (log-rank = 27.23, p < 0.001), and had a higher chance of experiencing long-term COVID-19 cardiovascular symptoms. Specifically, fatigue and dyspnea (57.7% and 62.8%, with p-values of 0.009 and <0.001, respectively) are among the most common. Conclusions: After surviving the acute phase, patients with elevated troponin on discharge present increased mortality and long-term COVID-19 symptoms over time, which is clinically relevant in follow-up visits.12 p.application/pdfengcc by (c) Vazirani, Ravi et al., 2024http://creativecommons.org/licenses/by/3.0/es/COVID-19MiocardiopatiesCOVID-19Myocardiopathiesinfo:eu-repo/semantics/article2024-06-20info:eu-repo/semantics/openAccess38731127