Pérez Recio, SandraPallarès, NatàliaGrijota Camino, Mª de los DesamparadosSánchez Montalvá, AdriánBarcia, LauraCampos Gutiérrez, SilviaPomar, VirginiaRabuñal Rey, RamónBalcells, Maria ElviraGazel, DenizMontiel, NataliaVicente, DiegoGoić-Barišić, IvanaSchön, ThomasPaues, JakobMareković, IvanaCacho Calvo, JuanaBarac, AleksandraGoletti, DeliaGarcía Gasalla, MercedesBarcala, José MariaTórtola, María TeresaAnibarro, LuisSuárez Toste, IsabelMoga, EstherGude Gonzalez, María J.Naves, RodrigoKarslıgil, TekinMartin Peñaranda, TaniaStevanovic, GoranTrigo, MatildeRubio, VerónicaKaraoğlan,, IlkayBayram, NazanAlcaide, FernandoTebé, CristianSantín Cerezales, Miguel2022-02-022022-02-022021-11-102165-0497https://hdl.handle.net/2445/182859We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB22TB1 value .0.6 IU ml21 was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2.TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB22TB1 result of .0.6 IU ml21 and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 5.4%, and 17.7% with close, frequent, and sporadic contact had a TB2.TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB22TB1 difference of .0.6 IU ml21 was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection.application/pdfengcc-by (c) Pérez Recio, Sandra et al., 2021https://creativecommons.org/licenses/by/4.0/Proves funcionals (Medicina)TuberculosiFunction tests (Medicine)Tuberculosisinfo:eu-repo/semantics/article7161612022-02-02info:eu-repo/semantics/openAccess