Frade Sosa, BeatrizPonce, AndrésInciarte Mundo, JoséMorla, RosaRuíz Esquide, VirginiaMacías Muñoz, LauraAzuaga, Ana BelénRamírez, JulioCañete Crespillo, Juan D.Yagüe, JordiAuge, Josep MariaGómez Puerta, José A.Sanmartí Sala, Raimon2024-01-292024-01-2920221759-7218https://hdl.handle.net/2445/206552To analyse the accuracy of plasma calprotectin in patients with rheumatoid arthritis (RA) receiving monoclonal antibodies against IL-6 receptors (anti-rIL-6) or JAK inhibitors (JAKis) in detecting ultrasound (US) synovitis and compare it with acute phase reactants [high-sensitivity C-reactive protein (hs-CRP) and ESR].An observational cross-sectional study of RA patients receiving anti-rIL-6 (tocilizumab or sarilumab) or JAKi, (baricitinib or tofacitinib) was made. Plasma calprotectin for the diagnosis of US synovitis [synovial hypertrophy grade (SH)???2 plus power Doppler signal (PD)???1] was analysed using receiver operating characteristic curves (ROCs). The performance of ESR and hs-CRP was also studied. The three ROC curves were compared to determine which had the highest discriminatory power. Associations between plasma calprotectin and US scores were made using correlation analysis.Sixty-three RA patients were included. Mean plasma calprotectin levels were significantly higher in patients with US synovitis than in those without (0.89?±?0.85 vs 0.30?±?0.12 ?g/ml; p?=?0.0003). A moderate correlation between calprotectin and all US scores (HS score Rho?=?0.479; PD score Rho?=?0.492; and global score Rho?=?0.495) was found. The discriminatory capacity of plasma calprotectin showed an AUC of 0.795 (95% CI: 0.687-0.904). The AUC of hs-CRP and ESR was 0.721 and 0.564, respectively. hs-CRP serum levels showed a low positive correlation with the three US scores (Rho?<?0.40). After analysis according to the drugs administered, the correlation disappeared in patients receiving anti-rIL-6.Plasma calprotectin may be a sensitive biomarker of synovial inflammation in RA patients treated with anti-rIL-6 or JAKi.© The Author(s), 2022.11 p.application/pdfengcc by-nc (c) Frade Sosa, Beatriz et al., 2022http://creativecommons.org/licenses/by-nc/3.0/es/Artritis reumatoideAnàlisi de proteïnesRheumatoid arthritisAnalysis of proteinsinfo:eu-repo/semantics/article2023-06-28info:eu-repo/semantics/openAccess933085036148395