Garza Puentes, Andrea de laMartí Alemany, AdriàChisaguano Tonato, Aida MaribelMontes Goyanes, RosaCastellote Bargalló, Ana IsabelTorres Espinola, Francisco JoséGarcía-Valdés, LuzEscudero-Marín, MireiaSegura Moreno, MaiteCampoy, CristinaLópez Sabater, María del Carmen2020-06-252020-06-252019-09-092072-6643https://hdl.handle.net/2445/166542This study analyzed how maternal obesity a ected fatty acids (FAs) in breast milk and their association with infant growth and cognition to raise awareness about the programming e ect of maternal health and to promote a healthy prenatal weight. Mother-child pairs (n = 78) were grouped per maternal pre-pregnancy body mass index (BMI): normal-weight (BMI = 18.5-24.99), overweight (BMI = 25-29.99) and obese (BMI > 30). Colostrum and mature milk FAs were determined. Infant anthropometry at 6, 18 and 36 months of age and cognition at 18 were analyzed. Mature milk exhibited lower arachidonic acid (AA) and docosahexaenoic acid (DHA), among others, than colostrum. Breast milk of non-normal weight mothers presented increased saturated FAs and n6:n3 ratio and decreased -linolenic acid (ALA), DHA and monounsaturated FAs. Infant BMI-for-age at 6 months of age was inversely associated with colostrum n6 (e.g., AA) and n3 (e.g., DHA) FAs and positively associated with n6:n3 ratio. Depending on the maternal weight, infant cognition was positively influenced by breast milk linoleic acid, n6 PUFAs, ALA, DHA and n3 LC-PUFAs, and negatively a ected by n6:n3 ratio. In conclusion, this study shows that maternal pre-pregnancy BMI can influence breast milk FAs and infant growth and cognition, endorsing the importance of a healthy weight in future generations.18 p.application/pdfengcc-by (c) Garza Puentes, Andrea de la et al., 2019http://creativecommons.org/licenses/by/3.0/esLlet maternaCreixementObesitatÀcids grassos omega-3CognicióDesenvolupament infantilBreast milkGrowthObesityOmega-3 fatty acidsCognitionChild developmentinfo:eu-repo/semantics/article6970122020-06-25info:eu-repo/semantics/openAccess31505767