Moncunill Piñas, GemmaMayor Aparicio, Alfredo GabrielJiménez, AlfonsNhabomba, Augusto J.Puyol, LauraManaca, Maria NéliaBarrios, DianaCisteró, PauGuinovart, CaterinaAguilar, RuthBardají, AzucenaPinazo, Maria-JesusAngov, EvelinaDutta, SheetijChitnis, Chetan E.Muñoz, JoséGascón i Brustenga, JoaquimDobaño, Carlota, 1969-2018-04-232018-04-232013-02-211932-6203https://hdl.handle.net/2445/121775Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n = 48), European adults (naïve travelers, n = 22; expatriates with few prior malaria exposures, n = 15) and Mozambican adults with long-life malaria exposure (n = 99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-142 (P = 0.030) and a P. falciparum isolate (P = 0.002), as well as higher IL-12 (P = 0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P≤0.0090), IL-2 (P≤0.0379) and IL-8 (P≤0.0233). Children also had higher IL-12 (P = 0.0001), IL-4 (P = 0.003), IL-1β (P = 0.024) and TNF (P = 0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A TH1/pro-inflammatory response was the hallmark of non-immune subjects.application/pdfengcc-by (c) Moncunill, Gemma et al., 2013http://creativecommons.org/licenses/by/3.0/esCitoquinesMalàriaPlasmodium falciparumCytokinesMalariaPlasmodium falciparuminfo:eu-repo/semantics/article6795952018-04-23info:eu-repo/semantics/openAccess23437061