Calvo Galve, NéstorAbrishamkar, AfshinSorrenti, AlessandroDi Rienzo, LorenzoSatta, MauroD'Abramo, MarcoCoronado, EugenioDe Mello, Andrew J.Mínguez Espallargas, GuillemPuigmartí-Luis, Josep2022-04-262022-04-262021-07-121433-7851https://hdl.handle.net/2445/185127Coordinationpolymers(CPs),includingmetal-organicframeworks(MOFs),are crystallinematerialswithpromisingapplicationsin electronics,magnetism,catalysis,andgas storage/separation.However,the mechanismsandpath-waysunderlyingtheirformationremainlargelyundisclosed.Herein,we demonstratethatdiffusion-controlledmixingofreagentsat the veryearlystagesof the crystallizationprocess(i.e., within 40 ms),achievedby usingcontinuous-flowmicrofluidicdevices,can be usedto enablenovelcrystallizationpathwaysofaprototypicalspin-crossover MOFtowards itsthermodynamicproduct.In particular,twodistinctandunprecedentednucleation-growth pathwayswere experimen-tallyobservedwhencrystallizationwas triggeredundermicro-fluidicmixing.Full-atommoleculardynamicssimulationsalsoconfirmthe occurrenceof thesetwo distinctpathwaysduringcrystalgrowth.In sharpcontrast,acrystallizationby particleattachmentwas observedunderbulk(turbulent)mixing.Theseunprecedentedresultsprovideasoundbasisfor understandingthe growth of CPsand openup newavenuesfor the engineer-ing of porousmaterialsby usingout-of-equilibriumconditions8 p.application/pdfengcc-by-nc (c) Calvo Galve, Néstor, et al., 2021http://creativecommons.org/licenses/by-nc/3.0/es/PolímersCristal·litzacióMicrofluídicaPolymersCrystallizationMicrofluidicsinfo:eu-repo/semantics/article7197502022-04-26info:eu-repo/semantics/openAccess