Rodríguez-Frías, FranciscoTabernero, DavidQuer, JosepEsteban, Juan I.Ortega, IsraelDomingo, EstebanCubero, MariaCamos, SílviaFerrer Costa, CarlesSànchez, Àlex (Sànchez Pla)Jardí, RosendoSchaper, MelanieHoms, MariaGarcía Cehic, DamirGuardia, JaumeEsteban, RafaelButi, Maria2013-05-072013-05-072012-05-301932-6203https://hdl.handle.net/2445/43202Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. In this study, the variability of an overlapping polymerase-surface region, critical for NA resistance, is investigated before treatment and under antiviral therapy, with assessment of NA-resistant amino acid changes simultaneously occurring in the same genome (linkage analysis) and their influence on the surface coding region.15 p.application/pdfengcc-by (c) Rodriguez Frías, F. et al., 2012http://creativecommons.org/licenses/by/3.0/esHepatitis BMedicaments antivíricsExpressió gènicaHepatitis BAntiviral agentsGene expressioninfo:eu-repo/semantics/article6142762013-05-07info:eu-repo/semantics/openAccess22666402