Vilaseca González, IsabelAvilés Jurado, Francesc XavierValduvieco, IzaskunBerenguer, JoanGrau, Juan JoséBaste, NeusMuxí Pradas, ÁfricaCastillo, PaolaLehrer, EduardoJordana, MartaRamírez Ruiz, Rosa DeliaCosta, José MiguelOleaga Zufiría, LauraBernal Sprekelsen, Manuel2023-03-142023-03-142021-09-271043-3074https://hdl.handle.net/2445/195211To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Background: To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Methods: Two hundred and two consecutive pT3-T4a larynx carcinomas. Pre-epiglottic space involvement, anterior and posterior paraglottic space (PGS) involvement, vocal cord, and arytenoid mobility were determined. Local control with laser (LC), overall survival (OS), disease-specific survival (DSS), and laryngectomy-free survival (LFS) were evaluated. Results: The lowest LC was found in tumors with fixed arytenoid. In the multivariate analysis, positive margins (hazard ratio [HR] = 0.289 [0.085-0.979]) and anterior (HR = 0.278 [0.128-0.605]) and posterior (HR = 0.269 [0.115-0.630]) PGS invasion were independent factors of a reduced LC. Anterior (HR = 3.613 [1.537-8.495]) and posterior (HR = 5.195 [2.167-12.455]) PGS involvement were independent factors of total laryngectomy. Five-year OS, DSS, and LFS rates were 63.9%, 77.5%, and 77.5%, respectively. Patients with posterior PGS presented a reduced 5-year LFS. Conclusions: Tumor classification according to laryngeal compartmentalization depicts strong correlation with LC and LFS.11 p.application/pdfengcc-by-nc-nd (c) Vilaseca González, Isabel et al., 2021http://creativecommons.org/licenses/by-nc-nd/3.0/es/Càncer de laringeMicrocirurgiaLàsers en cirurgiaCartílagTeixit connectiuLarynx cancerMicrosurgeryLasers in surgeryCartilageConnective tissueinfo:eu-repo/semantics/article7212322023-03-14info:eu-repo/semantics/openAccess34569120