Alguacil, JavierRobles i Brau, JordiRàfols Llach, ClaraBosch, Elisabeth2020-03-162020-03-1620160952-3499https://hdl.handle.net/2445/152818Isothermal titration calorimetry (ITC) is a powerful technique able to evaluate the energetics of target-drug binding within the context of drug discovery. In this work, the interactions of RNAs reproducing bacterial and human ribosomal A-site, with two well-known antibiotic aminoglycosides, Paromomycin and Neomycin, as well as several Neomycin-dinucleotide and -diPNA conjugates, have been evaluated by ITC and the corresponding thermodynamic quantities determined. The comparison of the thermodynamic data of aminoglycosides and their chemical analogues allowed to select Neomycin-diPNA conjugates as the best candidates for antimicrobial activity.9 p.application/pdfeng(c) John Wiley & Sons, 2016CalorimetriaAntibiòticsRNATermodinàmicaCalorimetryAntibioticsRNAThermodynamicsinfo:eu-repo/semantics/article6566912020-03-16info:eu-repo/semantics/openAccess