Hueso Val, MiguelRamon, Laura deNavarro, EstanisRipoll Llagostera, ÈliaCruzado, Josep Ma.Grinyó Boira, Josep M.Torras Ambròs, Joan2020-02-062020-02-062016-122352-3409https://hdl.handle.net/2445/149433Data presented in this Data in Brief article correspond to the article 'in vivo' silencing of CD40 reduces progression of experimental atherogenesis through a NFκB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis' (M. Hueso, L. De Ramon, E. Navarro, E. Ripoll, J.M. Cruzado, J.M. Grinyo, J. Torras, 2016) [1]. Here, we describe the validation of the silencing of CD40 expression with a specific siRNA in ApoE−/− mouse aortas, and its systemic effects on splenic lymphocytic subpopulations as well as on the infiltration of aortic intima by F4/80+, galectin-3+ macrophages or by NF-κB+ cells. We also show the output of a Gene Ontology and TLDA analysis which allowed the detection of potential mediators of atherosclerosis progression. We provide the scientific community with a set of genes whose expression is increased during atherosclerosis progression but downregulated upon CD40 silencing.8 p.application/pdfengcc-by (c) Hueso Val, Miguel et al., 2016http://creativecommons.org/licenses/by/3.0/esRNAMacròfagsAterosclerosiRatolins (Animals de laboratori)RNAMacrophagesAtherosclerosisMice (Laboratory animals)info:eu-repo/semantics/article6663782020-02-06info:eu-repo/semantics/openAccess27924297