Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count

Ruiz-de-Leon, Maria J.Jimenez-Sousa, Maria A.Moreno, SantiagoGarcia, MarcialGutierrez-Rivas, MonicaLeón García, AgatheMontero-Alonso, MartaGonzalez-Garcia, JuanResino, SalvadorRallón, NormaBenito, José M.Vallejo, AlejandroECRIS Network integrated in the Spanish AIDS Resea2020-06-012020-06-012019-08-011684-1182https://hdl.handle.net/2445/163507Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = −0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.5 p.application/pdfengcc-by-nc-nd (c) Taiwan Society of Microbiology, 2019http://creativecommons.org/licenses/by-nc-nd/3.0/esCèl·lules TVIH (Virus)Micro RNAsMarcadors bioquímicsT cellsHIV (Viruses)MicroRNAsBiochemical markersLower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell countinfo:eu-repo/semantics/article6934942020-06-01info:eu-repo/semantics/openAccess