Just Baringo, XavierYeste Vázquez, AlejandroMoreno Morales, JavierBallesté Delpierre, Clara CeliaVila Estapé, JordiGiralt Lledó, Ernest2022-03-292022-03-2920210947-6539https://hdl.handle.net/2445/184494The introduction of a novel tetra-ortho-chloroazobenzene amino acid (CEBA) has enabled photoswitching of the antimicrobial activity of tyrocidine A analogues by using exclusively visible light, granting spatiotemporal control under benign conditions. Compounds bearing this photo- switchable amino acid become active upon irradiation with red light, but quickly turn-off upon exposure to other visible light wavelengths. Critically, sunlight quickly triggers isomerisation of the red light-activated compounds into their original trans form, offering an ideal platform for self-deactivation upon release into the environment. Linear analogues of tyrocidine A were found to provide the best photocontrol of their antimicrobial activity, leading to compounds active against Acinetobacter baumannii upon isomerisation. Exploration of their N- and C-termini has provided insights into key elements of their structure and has allowed obtaining new antimicrobials displaying excellent strain selectivity and photocontrol.5 p.application/pdfengcc by-nc-nd (c) Just Baringo et al., 2021http://creativecommons.org/licenses/by-nc-nd/3.0/es/Espectroscòpia molecularAminoàcidsMolecular spectroscopyAmino acidsinfo:eu-repo/semantics/article7145212022-03-29info:eu-repo/semantics/openAccess