Vijai, JosephWang, ZhaomingBerndt, Sonja I.Skibola, Christine F.Slager, Susan L.Sanjosé Llongueras, Silvia deMelbye, MadsGlimelius, BengtBracci, Paige M.Conde, LucíaBirmann, Brenda M.Diver, W. RyanVajdic, Claire M.Armstrong, Bruce K.Kricker, AnneZheng, TongzhangHolford, Theodore R.Severi, GianlucaVineis, PaoloFerri, Giovanni M.Ricco, RosaliaMiligi, LuciaClavel, JacquelineGiovannucci, Edward L.Kraft, PeterVirtamo, JarmoSmith, AlexKane, EleanorRoman, EveChiu, Brian C. H.Fraumeni, Joseph F.Wu, XifengCerhan, James R.Offit, KennethChanock, Stephen J.Rothman, NathanielNieters, AlexandraWang, Sophia S.Brooks-Wilson, Angela R.Lan, QingBakker, Paul I. W. deVermeulen, Roel C. H.Portlock, CarolAnsell, Stephen M.Link, Brian K.Riby, JacquesNorth, Kari E.Gu, JianHjalgrim, HenrikCozen, WendyBecker, NikolausTeras, Lauren R.Spinelli, John J.Turner, JennyZhang, YaweiPurdue, Mark P.Giles, Graham G.Kelly, Rachel S.Zeleniuch-Jacquotte, AnneEnnas, Maria GraziaMonnereau, AlainBertrand, Kimberly A.Albanes, DemetriusLightfoot, TracyYeager, MeredithChung, Charles C.Burdett, LaurieHutchinson, AmyLawrence, CharlesMontalvan, RebeccaLiang, LimingHuang, JinyanMa, BaoshanVillano, Danylo J.Maria, AnnCorines, MarinaThomas, TinuNovak, Anne J.Dogan, AhmetLiebow, MarkThompson, Carrie A.Witzig, Thomas E.Habermann, Thomas M.Weiner, George J.Smith, Martyn T.Holly, Elizabeth A.Jackson, Rebecca D. J.Tinker, Lesley F.Ye, YuanqingAdami, Hans-OlovSmedby, Karin E.Roos, Anneclaire J. DeHartge, PatriciaMorton, Lindsay M.Severson, Richard K.Benavente, YolandaBoffetta, PaoloBrennan, PaulForetova, LenkaMaynadié, MarcMcKay, James D.Staines, Anthony2018-11-162018-11-162015-01-08https://hdl.handle.net/2445/126171Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.application/pdfengcc by (c) Vijai et al., 2015http://creativecommons.org/licenses/by/3.0/es/Malaltia de HodgkinCèl·lules BHodgkin's diseaseB cellsinfo:eu-repo/semantics/article2018-07-24info:eu-repo/semantics/openAccess25569183