Bosch, CarolineLópez-Lledó, PabloBonjoch i Sesé, JosepBradshaw, BenNieuwland, Pieter J.Blanco-Ania, DanielRutjes, Floris P. J. T.2019-02-192019-02-192016-05-312062-249Xhttps://hdl.handle.net/2445/128411An Amberlite IR 120 H-promoted one-pot Fischer indolization from a cis-decahydroquinoline using a range of phenylhydrazines led to compounds with the pyrido[2,3-a]carbazole scaffold. The process may be conducted either in batch mode or in a continuous manner in a flow reactor. The stereochemical course of the Fischer indole reaction changed in going from using free phenylhydrazine to the corresponding hydrochloride in batch conditions, whereas, with the short reaction times in continuous flow, no changes due to isomerization processes were observed. Keywords: Fischer indole synthesis, one-pot synthesis, continuous-flow synthesis, sulfonic acid resin, immobilized reagents, pyrido[2,3-a]carbazoles4 p.application/pdfeng, 2016Síntesi en fase sólidaCompostos heterocíclicsÀcids orgànicsSíntesi orgànicaSolid-phase synthesisHeterocyclic compoundsOrganic acidsOrganic synthesisinfo:eu-repo/semantics/article6666402019-02-19info:eu-repo/semantics/openAccess