Bernardi, StefanoBo', Cristian DelGuglielmetti, SimoneCherubini, AntonioKroon, Paul A.Kirkup, BenjaminHidalgo Liberona, NicolePeron, GregorioGonzález-Domínguez, RaúlAndrés Lacueva, Ma. CristinaRiso, Patrizia2020-05-122020-05-122019-08-162504-3900https://hdl.handle.net/2445/159731The inevitable rise of the proportion of people aged >65 years worldwide is paralleled by an increased burden of chronic diseases often associated with low-grade systemic inflammation. Recent findings suggest a link between inflammation and intestinal permeability (IP), a condition characterized by an impairment of intestinal barrier function which enables the translocation of dietary and bacterial factors into the blood activating the host immune system [1,2]. Dietary components can be significant modulators of inflammation and IP, and can also affect the intestinal microbial ecosystem. In the context of a diet-microbiota-IP axis in older subjects, dietary bioactives such as polyphenols may play a significant protective role due to their widely reported antioxidant and immunomodulatory properties and potential to regulate IP [3-6].2 p.application/pdfengcc-by (c) Bernard, Stefano et al., 2019http://creativecommons.org/licenses/by/3.0/esMalalties cròniquesPersones gransMalalties inflamatòries intestinalsChronic diseasesOlder peopleInflammatory bowel diseasesinfo:eu-repo/semantics/article6990692020-05-12info:eu-repo/semantics/openAccess