Fraser, MayaMiller, John M.Silumbe, KafulaHainsworth, MichaelMudenda, MutintaHamainza, BusikoMoonga, HawelaChizema Kawesha, ElizabethMercer, Laina D.Bennett, AdamSchneider, KammerleSlater, HannahEisele, Thomas P.Guinovart, Caterina2022-02-142022-02-1420210022-1899https://hdl.handle.net/2445/183068BACKGROUND NlmCategory: BACKGROUND content: In 2016, the Zambian National Malaria Elimination Centre started programmatic mass drug administration (pMDA) campaigns with dihydroartemisinin-piperaquine as a malaria elimination tool in Southern Province. Two rounds were administered, two months apart (coverage 70% and 57% respectively). We evaluated the impact of one year of pMDA on malaria incidence using routine data. - Label: METHODS NlmCategory: METHODS content: We conducted an interrupted time series with comparison group analysis on monthly incidence data collected at the health facility catchment area (HFCA) level, with a negative binomial model using generalized estimating equations. pMDA was conducted in HFCAs with greater than 50 cases/1,000 people/year. Ten HFCAs with incidence rates marginally above this threshold (pMDA group) were compared to 20 HFCAs marginally below (comparison group). - Label: RESULTS NlmCategory: RESULTS content: "The pMDA HFCAs saw a 46% greater decrease in incidence at the time of intervention than the comparison areas (incidence rate ratio: 0.536 [0.337-0.852]); however, incidence increased toward the end of the season. No HFCAs saw a transmission interruption." - Label: CONCLUSION NlmCategory: CONCLUSIONS content: pMDA, implemented during one year with imperfect coverage in low transmission areas with sub-optimal vector control coverage, significantly reduced incidence. However, elimination will require additional tools. Routine data are important resources for programmatic impact evaluations and should be considered for future analyses.9 p.application/pdfengcc by (c) Fraser, Maya et al, 2021http://creativecommons.org/licenses/by/3.0/es/MalàriaPolítica sanitàriaMalariaMedical policyinfo:eu-repo/semantics/article2022-02-11info:eu-repo/semantics/openAccess32691047