Benavent Palomares, EvaMorata, LauraEscrihuela Vidal, FrancescReynaga, Esteban AlbertoSoldevila-Boixader, LauraAlbiach, LaiaPedro Botet, Maria LuisaPadullés Zamora, AriadnaSoriano Viladomiu, AlexMurillo Rubio, Óscar2021-02-242021-02-242021-01-01https://hdl.handle.net/2445/174217Background: To evaluate the efficacy and safety of long-term use of tedizolid in osteoarticular infections. Methods: Multicentric retrospective study (January 2017–March 2019) of osteoarticular infection cases treated with tedizolid. Failure: clinical worsening despite antibiotic treatment or the need of suppressive treatment. Results: Cases (n = 51; 59% women, mean age of 65 years) included osteoarthritis (n = 27, 53%), prosthetic joint infection (n = 17, 33.3%), and diabetic foot infections (n = 9, 18%); where, 59% were orthopedic device-related. Most frequent isolates were Staphylococcus spp. (65%, n = 47; S. aureus, 48%). Reasons for choosing tedizolid were potential drug-drug interaction (63%) and cytopenia (55%); median treatment duration was 29 days (interquartile range -IQR- 15–44), 24% received rifampicin (600 mg once daily) concomitantly, and adverse events were scarce (n = 3). Hemoglobin and platelet count stayed stable throughout treatment (from 108.6 g/L to 116.3 g/L, p = 0.079; and 240 × 109/L to 239 × 109/L, p = 0.942, respectively), also in the subgroup of cases with cytopenia. Among device-related infections, 33% were managed with implant retention. Median follow-up was 630 days and overall cure rate 83%; among failures (n = 8), 63% were device-related infections. Conclusions: Long-term use of tedizolid was effective, showing a better safety profile with less myelotoxicity and lower drug-drug interaction than linezolid. Confirmation of these advantages could make tedizolid the oxazolidinone of choice for most of osteoarticular infections.10 p.application/pdfengcc by (c) Benavent Palomares et al., 2021http://creativecommons.org/licenses/by/3.0/es/DiabetisInteraccions dels medicamentsDiabetesDrug interactionsinfo:eu-repo/semantics/article7200162021-02-08info:eu-repo/semantics/openAccess33429902