Haddad Tovolli, RobertaMorari, JoseaneBarbizan, RobertaBóbbo, VanessaCarraro, RodrigoSolon, CarinaDragano, NathaliaTorsoni, MárcioAraujo, ElianaVelloso, Licio2023-11-152024-02-022023-02-021522-1555https://hdl.handle.net/2445/203656Maternal dietary habits directly influence offspring health. In this study, we aimed at determining the impact of maternal obesity on BBB integrity. We show that DIO offspring presented a leakier ME–BBB, accompanied by changes in the expression of transcripts encoding for endothelial and tanycytic proteins, as well as of hypothalamic neuropeptides. Breastfeeding in lean dams was sufficient to protect the offspring from ME–BBB disruption, providing a preventive strategy of nutritional intervention during early life.13 p.application/pdfeng(c) The American Physiological Society, 2023ObesitatMaternitatObesityMotherhoodinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess36598900