Navasa, MiquelGarcía Pagán, Juan CarlosBosch i Genover, JaumeRiera, J. R.Bañares, RafaelMas Comas, Ana M.Bruguera i Cortada, Miquel, 1942-Rodés, J.2011-07-072011-07-0719920017-5749https://hdl.handle.net/2445/18676Twenty five patients with acute liver failure were measured for hepatic venous pressure gradient as an index of portal pressure during the course of a transjugular liver biopsy. Hepatic venous pressure gradient ranged from 4 to 24.5 mm Hg with a mean of 12.8 (5.3) mm Hg (normal values less than 5 mm Hg). All patients but one had increased portal pressure gradient. Portal hypertension correlated with the degree of architectural distortion of the liver, as suggested by a direct correlation between hepatic venous pressure gradient and the area of reticulin collapse, evaluated by means of a morphometric analysis on Sirius red stained liver slides (r = 0.43, p less than 0.05). Hepatic venous pressure gradient was significantly higher in patients with ascites (15.1 (5) mm Hg, n = 15) or renal failure (14.4 (5.3) mm Hg, n = 16) than in those without (9.3 (3.4) mm Hg and 10.1 (4) mm Hg, respectively; p less than 0.05). Portal hypertension was associated with systemic vasodilation and a hyperkinetic circulatory state, with decreased arterial pressure, and peripheral resistance and increased cardiac output.4 p.application/pdfeng(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1992Hipertensió portalMalalties del fetgeFetgePortal hypertensionLiver diseasesLiverinfo:eu-repo/semantics/article88651info:eu-repo/semantics/openAccess1644339