Gracia, CarolinaIsidro Llobet, AlbertCruz, Luis J.Acosta, Gerardo A.Álvarez Domingo, MercedesCuevas, CarmenGiralt Lledó, ErnestAlbericio Palomera, Fernando2013-12-202013-12-2020060022-3263https://hdl.handle.net/2445/48635Kahalalide compounds are peptides that are isolated from a Hawaiian herbivorous marine species of mollusc, Elysia rufescens, and its diet, the green alga Bryopsis sp. Kahalalide F and its synthetic analogues are the most promising compounds of the Kahalalide family because they show anti-tumoral activity. Linear solid-phase syntheses of Kahalalide F have been reported. Here we describe several new improved synthetic routes based on convergent approaches with distinct orthogonal protection schemes for the preparation of Kahaladide analogues. These strategies allow a better control and characterization of the intermediates because more reactions are performed in solution. Five derivatives of Kahalalide F were synthesized using several convergent approaches.application/pdfeng(c) American Chemical Society , 2006PèptidsMedicaments antineoplàsticsProductes naturals marinsPeptidesAntineoplastic agentsMarine natural productsinfo:eu-repo/semantics/article5490962013-12-20info:eu-repo/semantics/openAccess