Ramchuran, Estelle J.Pérez Guillén, IsabelBester, Linda A.Khan, RenéAlbericio Palomera, FernandoViñas, MiquelTorre, Beatriz G. de la2021-07-132021-07-132021-06-102079-6382https://hdl.handle.net/2445/178991Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we describe a new AMP family, namely the supercationic peptide dendrimers (SCPDs). Although all members of the series exert some antibacterial activity, we propose that special attention should be given to (KLK)2KLLKLL-NH2 (G1KLK-L2KL2), which shows selectivity for Gram-negative bacteria and virtually no cytotoxicity in HepG2 and HEK293. These results reinforce the validity of the SCPD family as a valuable class of AMP and support G1KLK-L2KL2 as a strong lead candidate for the future development of an antibacterial agent against Gram-negative bacteria.13 p.application/pdfengcc-by (c) Ramchuran, Estelle J. et al., 2021https://creativecommons.org/licenses/by/4.0/Síntesi en fase sólidaPèptidsAntibiòticsBacteris gramnegatiusSolid-phase synthesisPeptidesAntibioticsGram-negative bacteriainfo:eu-repo/semantics/article7127452021-07-13info:eu-repo/semantics/openAccess