Fernández de Misa, RicardoHernández Machín, B.Servitje Bedate, OctavioValentí Medina, FrancescMaroñas Jiménez, L.Ortiz Romero, Pablo LuisSánchez Schmidt, JúliaPujol, Ramon M.Gallardo, F. (Fernando)Pau Charles, I.Garcia-Muret, Maria P.Pérez Gala, S.Román, ConcepciónCañueto, J.Blanch Rius, L.Izu, RosaOrtiz Brugués, AriadnaMartí, Rosa M.Blanes, M.Morillo, MercedesSánchez, P.Peñate, YeraiBastida, J.Pérez Gil, AmaliaLopez Lerma, IngridMuniesa Montserrat, CristinaEstrach Panella, Ma. Teresa (María Teresa)2018-02-262018-10-102018-030307-6938https://hdl.handle.net/2445/120231Background: Data regarding response to treatment in lymphomatoid papulosis (LyP) are scarce. Aim: To assess the daily clinical practice approach to LyP and the response to first-line treatments. Methods: This was a retrospective study enrolling 252 patients with LyP. Results: Topical steroids, methotrexate and phototherapy were the most common first-line treatments, prescribed for 35%, 20% and 14% of the patients, respectively. Complete response (CR) was achieved in 48% of treated patients. Eczematous lesions significantly increased relative risk (RR) of not achieving CR (RR = 1.76; 95% CI 1.16-2.11). Overall median time to CR was 10 months (95% CI 6-13 months), and 78% of complete responders showed cutaneous relapse; both results were similar for all treatment groups (P > 0.05). Overall estimated median disease-free survival (DFS) was 11 months (95% CI 9-13 months) but DFS for patients treated with phototherapy was 23 months (95% CI 10-36 months; P < 0.03). Having the Type A LyP variant (RR = 2.04; 95% CI 0.96-4.30) and receiving a first-line treatment other than phototherapy (RR = 5.33; 95% CI 0.84-33.89) were significantly associated with cutaneous early relapse. Of the 252 patients, 31 (13%) had associated mycosis fungoides unrelated to therapeutic approach, type of LyP or T-cell receptor clonality. Conclusions: Current epidemiological, clinical and pathological data support previous results. Topical steroids, phototherapy and methotrexate are the most frequently prescribed first-line treatments. Although CR and cutaneous relapse rates do not differ between them, phototherapy achieves a longer DFS. Presence of Type A LyP and use of topical steroid or methotrexate were associated with an increased risk of early relapse.7 p.application/pdfeng(c) British Association of Dermatologists, 2017LimfomesMalalties de la pellFototeràpiaLymphomasSkin diseasesPhototherapyinfo:eu-repo/semantics/article6740762018-02-26info:eu-repo/semantics/openAccess28994134