Oriola Santandreu, DavidCasademunt i Viader, Jaume2019-05-162019-05-162013-07-260031-9007https://hdl.handle.net/2445/133320KIF1A is a kinesin motor protein that can work processively in a monomeric (single-headed) form by using a noise-driven ratchet mechanism. Here, we show that the combination of a passive diffusive state and finite-time kinetics of adenosine triphosphate hydrolysis provides a powerful mechanism of cooperative force generation, implying for instance that ∼ 10 monomeric KIF1As can team up to become ∼ 100 times stronger than a single one. Consequently, we propose that KIF1A could outperform conventional (double-headed) kinesin collectively and thus explain its specificity in axonal trafficking. We elucidate the cooperativity mechanism with a lattice model that includes multiparticle transitions.5 p.application/pdfeng(c) American Physical Society, 2013Proteïnes quinasesMonòmersProtein kinasesMonomersinfo:eu-repo/semantics/article6296512019-05-16info:eu-repo/semantics/openAccess