Lloberas Cavero, JorgeValverde Estrella, LorenaTur Torres, JuanVico Rivero, TaniaCelada Cotarelo, Antonio2016-07-072016-07-072016-06-28https://hdl.handle.net/2445/100209Macrophages are necessary in multiple processes during the immune response or inflammation. This review emphasizes the critical role of the mitogen-activated protein kinases (MAPKs) and mitogen kinase phosphatase-1 (MKP-1) in the functional activities of macrophages. While the phosphorylation of MAPKs is required for macrophage activation or proliferation, MKP-1 dephosphorylates these kinases, thus playing a balancing role in the control of macrophage behavior. MKP-1 is a nuclear-localized dual-specificity phosphatase whose expression is regulated at multiple levels, including at the transcriptional and post-transcriptional level. The regulatory role of MKP-1 in the interplay between MAPK phosphorylation/dephosphorylation makes this molecule a critical regulator of macrophage biology and inflammation.8 p.application/pdfengcc-by (c) Lloberas et al., 2016http://creativecommons.org/licenses/by/3.0/esEnzimsMacròfagsEsterasesEnzymesMacrophagesEsterasesinfo:eu-repo/semantics/article6629582016-07-07info:eu-repo/semantics/openAccess27446931