Rubio, RaülPalacios, BeatrizVarela, LuisGutiérrez Ibañez, MartínCamargo Correa, SeleneCalvo Barriuso, ElenaJosé Bazán, NuriaYun Viladomat, SergiSoria Gómez, María TeresaMontero Hernández, EstherHidalgo, EncarnaEnjuanes, CristinaRueda, YolandaSan Saturnino, MaiteGarcimartín Cerezo, PalomaLópez Ibor, Jorge V.Segovia Cubero, JavierComín Colet, Josep2025-08-272025-08-272025-07-032077-0383https://hdl.handle.net/2445/222781Background/Objectives: Evidence of patient experiences with heart failure with preserved ejection fraction (HFpEF) and disease impact on quality of life (QoL) is scarce. This study explored perceived impacts on QoL and healthcare experiences of HFpEF patients and their caregivers. Methods: This was a mixed-methods study with HFpEF patients, >= 40 years, New York Heart Association functional classes I-IV in Spain. Qualitative data were collected through semi-structured interviews with patients (n = 19) and caregivers (n = 17). The EuroQoL 5D-5L, Patient Global Impression of Severity, and Kansas City Cardiomyopathy Questionnaire were used to collect QoL measures. Results: The themes were as follows. (1) Impact of HFpEF on QoL; (2) new roles of informal caregiving; and (3) the increasing value of multidisciplinary care. Qualitative data were supported by a trend of worsening QoL on quantitative measures as HF progressed, despite quantitative measures not fully capturing the burden. Qualitative data further captured discrepancies of QoL perceptions. Conclusions: The impact of HFpEF on patients and their caregivers was similar to the HFrEF population's. Insights from discrepancies between PROMs data and interviews could help with tailoring QoL questionnaires to capture the broader impact of HFpEF, identify unmet needs, and customize care.22 p.application/pdfengcc-by (c) Rubio, Raül et al., 2025http://creativecommons.org/licenses/by/3.0/es/Insuficiència cardíacaQualitat de vidaSatisfacció dels pacientsCuidadorsHeart failureQuality of lifePatient satisfactionCaregiversQuality of life and experience of patients with heart failure with preserved ejection fraction and their caregiversinfo:eu-repo/semantics/article2025-08-19info:eu-repo/semantics/openAccess40649089