Albert Mach, JoanAriza Piquer, XavierCalvet Pallàs, Maria TeresaFont Bardia, Ma. MercedesGarcía Gómez, JordiGranell Sanvicente, Jaime RamónLamela, AndreaLópez Barallobre, BlancaMartínez López, Manuel, 1957-Ortega, LauraRodríguez Ramírez, AleixSantos, David2013-05-212014-12-3120130276-7333https://hdl.handle.net/2445/43589An unusual NH2-directed Pd(II)-catalytic carbonylation of quaternary aromatic α-amino esters to yield benzolactams has been developed. The steric hindrance around the amino group is pivotal for the success of the process. The stoichiometric cyclometallation of a variety amino esters has been studied in order to evaluate the influence of the different variables (size of the metallacycle, aromatic ring substituents, and steric bulk) in the process, and a complete kinetico-mechanistic study of the cyclopalladation process has been carried out. The experimental results indicate that the full substitution of the carbon in the α position of the amino esters plays an important role in their cyclopalladation reaction. The reaction shows a strong bias to 6-membered lactams over the 5-membered analogues, which can be explained by a greater reactivity of the six-membered palladacycles.36 p.application/pdfeng(c) American Chemical Society , 2013Pal·ladi (Element químic)Cinètica químicaCompostos organometàl·licsCristal·lografiaCatàlisiPalladiumChemical kineticsOrganometallic compoundsCrystallographyCatalysisinfo:eu-repo/semantics/article6197352013-05-17info:eu-repo/semantics/openAccess