Vega Peñaloza, AlbertoSantiago Abelleira, Danae2025-08-262025-06https://hdl.handle.net/2445/222776Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2025, Tutor: Alberto Vega PeñalozaLight-mediated reactions offer a powerful platform for exploring chemical reactivity through controlled photoexcitation. This project focuses on advancing photoinduced reactions via electron donor-acceptor (EDA) complex activation, where interactions between an electron-rich donor and an electron-deficient acceptor generate reactive radicals under visible-light irradiation. Crucially, this approach operates without external catalysts—such as traditional metal-based photocatalysts—or sacrificial additives, enhancing synthetic efficiency. Central to our study is the functionalization of oxindoles, a privileged scaffold in medicinal chemistry due to the potent bioactivity of its derivatives. To achieve this, we designed and synthesized an oxindole-derived enol ether (donor 1) and paired it with Katritzky salts (acceptors 3 and 4) as complementary EDA complex partners. UV-visible spectroscopy confirmed EDA complex formation through the characteristic charge-transfer band (CT), while also identifying the optimal irradiation wavelength to maximize product formation and minimize byproduct generation. These findings establish a foundation for developing a mild, efficient, and catalyst-free methodology for oxindole functionalization. Future work will expand the scope of this reactivity and refine reaction conditions to enhance synthetic utility.36 p.application/pdfengcc-by-nc-nd (c) Santiago, 2025http://creativecommons.org/licenses/by-nc-nd/3.0/es/FotoquímicaLlum visibleTreballs de fi de grauPhotochemistryVisible lightBachelor's thesesinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/embargoedAccess