Cantero, IreneAbete, ItziarBabio, NancyArós, FernandoCorella Piquer, DoloresEstruch Riba, RamonFitó Colomer, MontserratHébert, James R.Martínez-González, Miguel Ángel, 1957-Pintó Sala, XavierPortillo, María PuyRuiz Canela, MiguelShivappa, NitinWärnberg, JuliaGómez Gracia, EnriqueTur, Josep AntoniSalas Salvadó, JordiZulet, M. AngelesMartínez, J. Alfredo, 1957-2019-12-042019-12-042018-100261-5614https://hdl.handle.net/2445/146044BACKGROUND & AIMS: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. METHODS: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-α and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. RESULTS: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. CONCLUSIONS: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity.8 p.application/pdfengcc-by-nc-nd (c) Elsevier Ltd and European Society for Clinical Nutrition and Metabolism, 2018http://creativecommons.org/licenses/by-nc-nd/3.0/esMalalties del fetgeTeixit adipósLiver diseasesAdipose tissuesinfo:eu-repo/semantics/article6881062019-12-04info:eu-repo/semantics/openAccess