Papantoniou, KyriakiCastaño-Vinyals, GemmaEspinosa, AnaTurner, Michelle C.Martín Sánchez, VicenteCasabonne, DelphineAragonès Sanz, NúriaGómez Acebo, InésArdanaz, EvaJimenez Moleon, Jose JuanAmiano, PilarMolina Barceló, AnaAlguacil, JuanFernández Tardón, GuillermoHuerta, José MaríaHernández Segura, NataliaPérez Gómez, BeatrizLlorca, JavierVidán Alli, JuanaOlmedo Requena, RocíoGil, LeireCastañon López, CarmenPollan, MarinaKogevinas, ManolisMoreno Aguado, Víctor2021-07-192021-07-192021-06-032045-2322https://hdl.handle.net/2445/179173Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case-control study (2008-2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR≥9 hours: 1.59; 95%CI 1.30-1.94) and gastric cancer (OR≥9 hours: 1.95; 1.37-2.76); short sleep was associated with increased odds of gastric cancer (OR≤5 hours: 1.32; 0.93-1.88). Frequent and long daytime naps increased the odds of colorectal (OR6-7 naps/week, ≥30 min: 1.32; 1.14-1.54) and gastric cancer (OR6-7 naps/week, ≥30 min: 1.56; 1.21-2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.14 p.application/pdfengcc by (c) Papantoniou, Kyriaki et al., 2021http://creativecommons.org/licenses/by/3.0/es/Càncer gastrointestinalFactors de risc en les malaltiesSonCáncer gastrointestinalColorectal cancerRisk factors in diseasesSleepGastrointestinal cancerinfo:eu-repo/semantics/article7214132021-07-16info:eu-repo/semantics/openAccess34083698