González Tarragó, VíctorElosegui Artola, AlbertoBazellières, ElsaOria, RogerPérez González, CarlosRoca-Cusachs Soulere, Pere2018-07-062018-07-062017-03-011059-1524https://hdl.handle.net/2445/123393Fundamental processes in cell adhesion, motility, and rigidity adaptation are regulated by integrin-mediated adhesion to the extracellular matrix (ECM). The link between the ECM component fibronectin (fn) and integrin α5β1 forms a complex with ZO-1 in cells at the edge of migrating monolayers, regulating cell migration. However, how this complex affects the α5β1-fn link is unknown. Here we show that the α5β1/ZO-1 complex decreases the resistance to force of α5β1-fn adhesions located at the edge of migrating cell monolayers while also increasing α5β1 recruitment. Consistently with a molecular clutch model of adhesion, this effect of ZO-1 leads to a decrease in the density and intensity of adhesions in cells at the edge of migrating monolayers. Taken together, our results unveil a new mode of integrin regulation through modification of the mechanical properties of integrin-ECM links, which may be harnessed by cells to control adhesion and migration.6 p.application/pdfengcc-by-nc-sa (c) González Tarragó, Víctor et al., 2017http://creativecommons.org/licenses/by-nc-sa/3.0/esMotilitat cel·lularMigració cel·lularBiologia molecularCell motilityCell migrationMolecular biologyinfo:eu-repo/semantics/article6785022018-07-06info:eu-repo/semantics/openAccess28251923