Aguilar-Recarte, DavidPalomer Tarridas, Francesc XavierWahli, WalterVázquez Carrera, Manuel2022-03-082022-03-082021-08-091661-6596https://hdl.handle.net/2445/183848The current treatment options for type 2 diabetes mellitus do not adequately control the disease in many patients. Consequently, there is a need for new drugs to prevent and treat type 2 diabetes mellitus. Among the new potential pharmacological strategies, activators of peroxisome proliferator-activated receptor (PPAR)β/δ show promise. Remarkably, most of the antidiabetic effects of PPARβ/δ agonists involve AMP-activated protein kinase (AMPK) activation. This review summarizes the recent mechanistic insights into the antidiabetic effects of the PPARβ/δ-AMPK pathway, including the upregulation of glucose uptake, muscle remodeling, enhanced fatty acid oxidation, and autophagy, as well as the inhibition of endoplasmic reticulum stress and inflammation. A better understanding of the mechanisms underlying the effects resulting from the PPARβ/δ-AMPK pathway may provide the basis for the development of new therapies in the prevention and treatment of insulin resistance and type 2 diabetes mellitus.application/pdfengcc-by (c) Aguilar-Recarte, David et al., 2021https://creativecommons.org/licenses/by/4.0/Trastorns del metabolisme dels lípidsÀcids grassosReceptors nuclears (Bioquímica)GlucosaLipid metabolism disordersFatty acidsNuclear receptors (Biochemistry)Glucoseinfo:eu-repo/semantics/article7137062022-03-08info:eu-repo/semantics/openAccess